Name | Source | Target Receptor | Target Cells | Functions | Recent Research |
Interleukin 1 |
Macrophages, B cells, Monocytes, Dendritic Cells |
CD121a/IL1R1, CD121b/ILR2 | T helper cells | Co-stimulation |
|
B cells | Maturation & Proliferation |
|
NK cells | Activation |
|
Macrophages, endothelium or other | Inflammation, small amount induce acute phase reaction, large amounts induce fever | IL-1 can itself produce hyperalgesia as assessed by tailflick to radiant heat |
Interleukin 2 | Th - 1 Cells | CD25/IL2RA, CD122/IL2RB, CD132/IL2RG | Activated T cells, B cells, NK cells, macrophages, oligodendrocyte | - Stimulate growth and differentiation of T cell response. - Can be used in immunotherapy to treat cancer or suppressed or transplant patients | High dose IL-2 produce durable responses in some patients with metastatic melanoma and should be considered a therapeutic option for appropriately selected patients with his disease. IL-2 released by lung T Cells in inactive pulmonary sarcoidosis |
Interleukin 3 | Activated T helper cells, mast cells, NK cells, endothelium, eosinophils | CD123/IL3RA, CD131/IL3RB | Hematopoietic stem cells | Differentiation and proliferation of myeloid progenitor cells Eg - erythrocytes & granulocytes | IL-3 supports growth of mouse pre B Cell clones in-vitro. |
Mast cell | Growth & histamine release |
|
Interleukin 4 | Th - 1 cells, activated naive CD4+ cell, memory CD4+ cells, mast cells, macrophages | CD124/IL4R, CD132/IL2RG | Activated B cells | Proliferation & differentiation, Ig G1 and Ig E synthesis. Important role in allergic response (Ig E) | Systemic sclerosis |
T cells | Proliferation |
|
Interleukin 5 | Th -2 cells, mast cell, eosinophils | CD125/IL5RA, CD131/IL3RB | Eosinophils | Production |
|
B Cells | Differentiation, Ig A production |
|
Interleukin 6 | Macrophages, Th - 2 cells, B cells, astrocytes, endothelium | CD126/IL6RA, CD130/IL6RB | Activated B cells | Differentiation into plasma cells |
|
Plasma cells | Antibody secretion |
|
Hematopoietic stem cells | Differentiation |
|
T Cells or Other | Induce acute phase reaction, hematopoiesis, differentiation, inflammation |
|
Interleukin 7 | Bone marrow, stromal cells & thymus stromal cells | CD127/IL7RA, CD132/IL2RG | Pre/pro- B cell, Pre/pro- T cell, NK cells | Differentiation and proliferation of lymphoid progenitor cells, involved B, T and NK cells survival, development and homeostasis, increase pro-inflammatory, cytokine | Show effect on T cells homeostasis |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
0 comments:
Post a Comment